Decomposing protein networks into domain-domain interactions
نویسندگان
چکیده
منابع مشابه
Decomposing protein networks into domain-domain interactions
UNLABELLED The application of novel experimental techniques has generated large networks of protein-protein interactions. Frequently, important information on the structure and cellular function of protein-protein interactions can be gained from the domains of interacting proteins. We have designed a Cytoscape plugin that decomposes interacting proteins into their respective domains and compute...
متن کاملDomain-Domain Interactions Underlying Herpesvirus-Human Protein-Protein Interaction Networks
Protein-domains play an important role in mediating protein-protein interactions. Furthermore, the same domain-pairs mediate different interactions in different contexts and in various organisms, and therefore domain-pairs are considered as the building blocks of interactome networks. Here we extend these principles to the host-virus interface and find the domain-pairs that potentially mediate ...
متن کاملProtein–protein interactions: PDZ domain networks
PDZ domains can dimerize or bind to the carboxyl termini of unrelated proteins. Crystallographic studies demonstrate the structural basis for these interactions, which contribute to the ability of PDZ domains to create networks associated with the plasma membrane.
متن کاملKnowledge-guided inference of domain–domain interactions from incomplete protein–protein interaction networks
MOTIVATION Protein-protein interactions (PPIs), though extremely valuable towards a better understanding of protein functions and cellular processes, do not provide any direct information about the regions/domains within the proteins that mediate the interaction. Most often, it is only a fraction of a protein that directly interacts with its biological partners. Thus, understanding interaction ...
متن کاملComputational Approaches to Predict Protein–protein and Domain–domain Interactions
Knowledge of protein and domain interactions provides crucial insights into their functions within a cell. Various high throughput experimental techniques such as mass spectrometry, yeast two hybrid, and tandem affinity purification have [Q3] generated a significant amount of large-scale high throughput protein interaction data [9,19,21,28,29,35,36,58]. Advances in experimental techniques are p...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Bioinformatics
سال: 2005
ISSN: 1367-4803,1460-2059
DOI: 10.1093/bioinformatics/bti1135